IJMS, Vol. 13, Pages 8071-8085: Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives

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¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, 34755, Kayisdagi, Istanbul, Turkey ² Department of Molecular Biology and Genetics, BilGen, Genetics and Biotechnology Research Center, Faculty of Science, Bilkent University, 06800, Bilkent, Ankara, Turkey

* Author to whom correspondence should be addressed.

Received: 18 May 2012; in revised form: 7 June 2012 / Accepted: 13 June 2012 / Published: 28 June 2012

Abstract: A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a?g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and ¹H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MAHLAVU, HEPG2, HEP3B), breast (MCF7, BT20, T47D, CAMA-1), colon (HCT-116), gastric (KATO-3) and endometrial (MFE-296) cancer cell lines. Time-dependent cytotoxicity analysis of compound 5a indicated the long-term in situ stability of this compound. All compounds showed significant cell growth inhibitory activity on the selected cancer cell lines.

Keywords: 1-(4-chlorobenzhydryl)piperazine derivatives; cell proliferation; benzoyl chlorides; cytotoxicity; cancer

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Cite This Article

MDPI and ACS Style

Yarim, M.; Koksal, M.; Durmaz, I.; Atalay, R. Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives. Int. J. Mol. Sci. 2012, 13, 8071-8085.

AMA Style

Yarim M., Koksal M., Durmaz I., Atalay R. Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives. International Journal of Molecular Sciences. 2012; 13(7):8071-8085.

Chicago/Turabian Style

Yarim, Mine; Koksal, Meric; Durmaz, Irem; Atalay, Rengul. 2012. "Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives." Int. J. Mol. Sci. 13, no. 7: 8071-8085.

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